Structural Phylogenetics

Date and Time: January, 9, 2021, 11 am – 1 pm SGT Speaker: Dr. Ashar Malik, Bioinformatics Institute, A*STAR, Singapore Abstract: The primary step in the process of characterising a novel protein sequence is by comparison with those already characterised. Similarity based functional characterisation and determination of an evolutionary origin can become a non-trivial problem for significantly diverged proteins. Protein structure, on the other hand, is considered to be conserved over longer evolutionary timescales. An evolutionary signal lost from the sequence may therefore still be retained within the conserved structure. Current times are seeing an exponential growth in protein structural…