3D substructure searching and comparisons: methods, applications and directions

Date and Time March 13, 2021, 11 AM – 12 pm SGT Speaker Assoc. Prof. Dr. Mohd Firdaus Raih Universiti Kebangsaan Malaysia Abstract The functions of biological macromolecules are dependent on their three-dimensional structures. Although the overall structure of these molecules is important for their functions, only a subset of residues is actively involved in a particular function mechanism. These functionally important residues are usually conserved as 3D substructures and/or motifs and are involved in molecular interactions as binding sites or catalytic mechanisms. In my research group, we have developed methods to identify and compare these 3D substructures in the…

Revolutionising Genome Analysis with Machine Learning and Cloud Computing

Date and Time: December 15, 2020, 1 – 2 pm SGT Speaker: Dr. Natalie Twine, Transformational Bioinformatics Group, CSIRO Abstract: Dr. Natalie Twine provides an insider’s view into the development of a Spark-based machine learning framework that is able to find disease genes in the 3 billion letters of the genome. She will also cover novel software, TRIBES, developed to uncover distant relatives based on their genome. Knowing relationship status is important for diagnosing and treating genetic diseases. Natalie will showcase how the technology has been used to understand and find treatments for motor neurone disease. Finally, Natalie will showcase…